tag:blogger.com,1999:blog-3492197469143963742.post6157351197377165315..comments2023-06-13T04:45:22.434-04:00Comments on Infection Landscapes: RotavirusMichael Walshhttp://www.blogger.com/profile/05038031388622939797noreply@blogger.comBlogger47125tag:blogger.com,1999:blog-3492197469143963742.post-34250171045968707562016-02-26T13:22:32.441-05:002016-02-26T13:22:32.441-05:00Since prevention seems like the only way to preven...Since prevention seems like the only way to prevent rotavirus infections/epidemics, further vaccine development is necessary. Since the only two vaccines available are live attenuated vaccines, they require a more extensive cold chain than an inactivated vaccine would. Thus, these live attenuated vaccines have less feasibility in reaching many of the resource-poor regions which are impacted by rotavirus. Would an inactivated vaccine work for this type of virus though?Anonymoushttps://www.blogger.com/profile/16027370189089578596noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-45083385005279397722016-02-25T09:35:42.728-05:002016-02-25T09:35:42.728-05:00An aspect of Rotavirus that I find very interestin...An aspect of Rotavirus that I find very interesting is how prevalent it can be with trillions of virions shed in each diarrhea episode combined with it’s resiliency in aquatic environments and in many environmental reservoirs. As noted, Rotavirus A infections are not only the main contributor of overall diarrheal episodes worldwide but also liable for more severe diarrheal cases especially among children under 5. Communities holding advanced hospital infrastructure perform dehydration therapy to around 2 million severe cases that is a significant amount. I wonder how many cases do not make it to a hospital due to limited access. Given the resiliency of the virus in the environment that make hygienic sanitation and water infrastructure practices not sufficient enough to counteract the transmission of disease, vaccinations seem like the best way to prevent disease. The successes in Mexico and Brazil send a good message of the importance of vaccination; however, as portrayed in the reading vaccinations estimated to prevent a little less that ½ of deaths due to Rotavirus A. With this in mind, I think additional public health efforts such as highlighting the importance of personal hygiene for adults and children can help reduce the incidence of the disease. Furthermore, efforts could be made to make sure vaccination programs are accessible in order to have successes like Mexico has displayed. This means providing resources not only in vaccines alone but also education of the importance of vaccines, clinics (stationary or mobile), health care workers and adequate roadways. Perhaps a multifaceted approach could increase the prevented deaths to more that ½ rather than less than ½. Carolyn Marie Kochhttps://www.blogger.com/profile/00433281016560472480noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-82525848419229775332015-10-22T21:58:22.979-04:002015-10-22T21:58:22.979-04:00Well said Karla. Rotavirus is one of the few path...Well said Karla. Rotavirus is one of the few pathogens where good infrastructure is not a protective value. That said, it's hard to ignore that the developed world has an almost infinitesimally small number of cases as compared to Africa or India. Since it's not due to the good plumbing, it must be either better hygiene or most likely, wide spread vaccination. Considering that the price range for Rota Teq or Pentavalent is $50 to $110 it seems like a small amount to pay for protecting a child. On the other hand, if most o fthe world lives on $2 a day , that would equate to one years salary!Roger Deohttps://www.blogger.com/profile/03646437175858809536noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-88209382685272204402015-10-02T10:15:21.684-04:002015-10-02T10:15:21.684-04:00Knowing that rotavirus is, as stated in the blog p...Knowing that rotavirus is, as stated in the blog post, “the most important cause of severe diarrhea episodes in children in the world,” it is imperative for people to take precautionary measures. According to the CDC, these include good hygiene (hand washing) and cleanliness; nonetheless, these might not be enough to control the spread of the disease since the virus can spread easily even when people try very hard to keep places clean. There are also rotavirus vaccines, which can be “very effective in preventing rotavirus gastroenteritis and the accompanying diarrhea and other symptoms” (CDC 2014). In fact, the CDC recommends routine vaccination of infants with either of the two available vaccines: “RotaTeq® (RV5), which is given in 3 doses at ages 2 months, 4 months, and 6 months; or Rotarix® (RV1), which is given in 2 doses at ages 2 months and 4 months” (CDC 2014). Furthermore, as explained in the post it is crazy to know that if there is a universal implementation of vaccination against rotavirus, a little less than half the “annual deaths reported each year (~ 250,000)” could be prevented (CDC 2014). Since it often infects babies and children, it is essential for parents and guardians to know the vital importance of maintaining good hygiene and of teaching their children to wash their hands, use hand sanitizers and taking other precautionary measures to prevent infection. <br /><br />Works Cited<br />Centers for Disease Control and Prevention (CDC). 2014. Prevention.<br />[Internet] Rotavirus. Retrieved from http://www.cdc.gov/rotavirus/about/prevention.html. <br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126576/pdf/ahmt-5-143.pdf<br />Anonymoushttps://www.blogger.com/profile/10812728419197385223noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-50040633858866262852015-09-03T21:34:12.361-04:002015-09-03T21:34:12.361-04:00Once again, what used to be a common "bug&quo...Once again, what used to be a common "bug" and major contributor of childhood mortality is now made almost obsolete (at least in our country) by universal vaccination. Rotavirus vaccines are usually given to infants. In New York State, the immunization schedule recommends 2-3 doses (RotaTeq, aka "RV5", requires three oral doses while Rotatrix, "RV1", requires only two). The first dose is given at age 2 months, with subsequent doses 2 months apart. As the article mentioned, both vaccines have been shown to be equally effective. For parents who are concerned about possible side effects-- rest assured, rotavirus immunization has shown to be safe! Although shedding and subsequent transmission of the virus does happen, especially during the first week after receiving the vaccination, symptoms usually do not develop in these cases. However, as health professionals, it is still a good idea to instruct caretakers and parents to thoroughly wash their hands after any contact with soiled material, such as diapers. This way, transmission of the vaccine-rotaviruses (also through the fecal-oral route) can be minimized. Lastly, one adverse event that has been associated with rotavirus vaccinations is intussusception. Intussusception is when a piece of bowel involutes, or "telescopes" on itself, causing cramping and even bloody, mucous-y stool. When severe, intussusception can cause a segment of bowel to die off. Because of this finding, infants with a history of intussusception are not recommended the rotavirus vaccine. Still, no need to worry! Herd immunity can still protect those that are not immunized!Anonymoushttps://www.blogger.com/profile/00094818324874815633noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-59446389100637398932015-07-10T16:03:09.238-04:002015-07-10T16:03:09.238-04:00I agree this vaccine is a tremendous resource. Per... I agree this vaccine is a tremendous resource. Perhaps even more valuable than the vaccine is the access to clean water, salts, and nutrients, that are unavailable in many parts of the world. The vast majority of children under the age of 5 have been infected with rotavirus at some point, and that is apparently irrespective of socioeconomic status or health infrastructure. What's interesting here then, is that the mortality as a result of diarrhea in infants varies markedly based on healthcare.<br /> This is compelling to me because it suggests that diarrhea treatment, and access to clean water, are much much more important than the development of a vaccine, because treatment for diarrhea is very effective and covers not just rotavirus, but the myriad other diarrheal diseases.Anonymoushttps://www.blogger.com/profile/00446188801114332575noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-71623752113427594622015-07-10T15:51:48.777-04:002015-07-10T15:51:48.777-04:00I don’t know that the alternative option to vaccin...I don’t know that the alternative option to vaccine is necessarily an improvement to quality of life concerning rotavirus in developing countries. The difference between life and death for these children is access to salt and sugar and a way of administering it. I think we are thinking along the same lines, but I believe the solution of access to care in this specific situation is more attainable than the more general- quality of life. I am not in any way implying that providing access to care for rotavirus infection will be the simplest feat, but it pales in comparison to the Goliath of QOL improvement in developing countries. Denise T.https://www.blogger.com/profile/11567218953952596413noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-91983773960884479712015-07-09T23:54:40.585-04:002015-07-09T23:54:40.585-04:00Dr Gul yes the rotavirus vaccine is highly effecti...Dr Gul yes the rotavirus vaccine is highly effective, I'm originally from Sudan, while growing up and visiting hospitals in the capital Khartoum the pediatric unit used to be filled to the prim with sick children, sometimes one bed has three children hooked to IV fluid and the majority of the cases were severe diarrhea and most children are between 1 to 5 years of age, some sadly die before they make it to the hospital and some develop acute severe malnutrition and dehydration.<br />In 2011 Sudan was the first GAVI eligible African country to introduce the Rotavirus vaccine in their immunization schedule and they have done a good job in distributing and immunizing children through stationary and mobile clinics, last year in December I visited one of the pediatrics units in one of the busiest children hospitals in Khartoum, the unit was less crowded that I saw before the vaccine era, it was obvious there was a significant reduction in severe diarrhea cases since the introduction of the vaccine four years ago, I hope they keep it up and more countries introduce the vaccine.Anonymoushttps://www.blogger.com/profile/16420001543069750611noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-33540684927603252092015-07-01T10:04:59.076-04:002015-07-01T10:04:59.076-04:00So far, this is the first virus I have read about ...So far, this is the first virus I have read about that shows no prejudice when it comes on to whom it infects. It recognizes not the disparities that we create on individual landscapes. But alas, here come the fangs of poverty to restrain the poor and even claim lives when it pertains to treatment! It never seizes to amaze me how little it takes to save a live, yet that “little” turns out to be “much” because the poor and destitute suffer from a lack of resources. In the case of the rotavirus, we see that the most vulnerable (children) in areas with very little resources die from dehydration. There is either little access to the treatment- sodium chloride, potassium chloride, citrate and glucose needed to save their lives, or more importantly, they lack the means to administer it. When we cannot rely solely on health education and it all boils down to a lack of resources, things become increasingly difficult. I guess we now have to do the math and try to at least attain the cheaper of the two solutions: vaccines or treatment.Denise T.https://www.blogger.com/profile/11567218953952596413noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-82068137879508242542015-06-19T09:14:35.302-04:002015-06-19T09:14:35.302-04:00I also found it quite staggering of how infectious...I also found it quite staggering of how infectious the rotavirus is in the youth of developing countries. It is interesting to note that although nearly all US children are infected before age 5, relatively very few (~20-60) deaths result. I believe that the low mortality rate may speak volumes about hygiene practices, healthcare and sanitation in the United States.Anonymoushttps://www.blogger.com/profile/16624706820510231248noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-68857951689428761232014-11-12T22:11:57.167-05:002014-11-12T22:11:57.167-05:00Like other RNA viruses, rotavirus has varied speci...Like other RNA viruses, rotavirus has varied species that contribute different factors to the components of the disease. For example, the pathogenicity of rotavirus is controlled by (NSP) 4, an enterotoxin that is responsible for stimulating diarrhea in the affected individual. It is interesting that this disease severely affects children globally and is the source of nutrient deficiency and severe dehydration constituting a medical emergency in poor geographic regions this group. It is not much a surprise since most children are a susceptible population because of their immature immunogenicity. Dr. Patel also points out the important factors of how getting treatment quickly and efficiently is usually not a reality for many children because of inaccessibility to healthcare with the proper resources to provide oral or intravenous rehydration needed to restore electrolyte imbalance, an occurrence of this disease.Nadine Blackwoodnoreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-84928782374643507222014-10-24T12:33:23.507-04:002014-10-24T12:33:23.507-04:00As mentioned above, rotavirus is highly infectious...As mentioned above, rotavirus is highly infectious but rarely affects adults. The subpopulation that experiences the greatest burden of disease is children younger than 5 years, with the most severe cases occurring between 6 months and 2 years. The mode of transmission may explain why rotavirus affects that particular subpopulation. Rotavirus is spread through fecal-oral transmission. As young children experience the diarrheal symptoms associated with rotavirus, their diapers are frequently changed. Although unintended, fecal matter may end up on a variety of surfaces. This possibility is even more common in daycares and schools. Several children in the same setting as an infected child may become infected. Young children tend to crawl, touch things and put things in their mouths. In addition, they may not practice adequate hygiene. These factors, in addition to the infectivity of the virus may explain its incidence among young children.Anonymoushttps://www.blogger.com/profile/10646013720531113340noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-31803128310642835932014-10-15T16:39:33.465-04:002014-10-15T16:39:33.465-04:00Since the advent of the vaccine, Rotavirus induces...Since the advent of the vaccine, Rotavirus induces gastroenteritis cases have significantly decreased. World health organization has made recommendations to include Rotavirus vaccine in the recommended pediatric vaccination regimen. <br />Rotavirus infection in the pediatric population has been implicated in the causing intussusception in which a portion of the intestine folds on itself causing a telescope appearance (inner circle and outer circle). The clinical trials results have shown cases of intussusception in individuals receiving the live rotavirus vaccine. <br /><br />https://www.merckvaccines.com/Products/RotaTeq/Pages/storageandhandling<br />Hariprasad Raohttps://www.blogger.com/profile/12186696543612891924noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-68306440319389811252014-09-24T16:39:44.913-04:002014-09-24T16:39:44.913-04:00Rotavirus is a viral pathogen known for causing a ...Rotavirus is a viral pathogen known for causing a deadly-diarrhea in individual infected. Rotavirus incidence is tied together with sanitation. The efforts taken to prevent the spread of rotavirus infection have been practiced however, possibly not practiced as properly as recommended. The most affect strategy used to prevent the spread of infection is vaccination; the vaccine is a live attenuated vaccine, which is estimated that it can prevent ½ the deaths associated with rotavirus infection. Rotavirus causes an infection that can lead to death however the weight of the disease is not fully understood and the infection seems to spread with ease. Hariprasad Raohttps://www.blogger.com/profile/12186696543612891924noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-78132001280399886462014-07-26T22:55:29.818-04:002014-07-26T22:55:29.818-04:00I agree with you Sarah that universal vaccination ...I agree with you Sarah that universal vaccination against rotavirus should be implemented, so naturally I researched these vaccines (1).Let’s begin with some limitations. Firstly, both Rotatrix (the attenuated human rotavirus vaccine) and Rotateq (the pentavalent human-bovine rotavirus reassortant vaccine) are not to be given to infants over the age of 8 months, because their effects have not been studied in any other age group. This presents a limitation for parents who have infants over that age. Secondly, Rotatrix is administered in two doses at age 2 and 4 months, and Rotateq in three doses at age 2, 4, and 6 months. This is a large burden on parents who might not remember the exact timing, might not expect multiple doses, or might have difficulty accessing the clinic for another dose (clinic might move, patient/parent might move), especially in a poverty-stricken area. It is a concern when the child gets a rotavirus infection before the dosing is complete, because the parents may be less likely to agree to another dose if they believe the vaccine was ineffective. Third, both vaccines are administered orally, which presents a challenge for the healthcare worker administering it. Babies may spit out or vomit the oral dose, and the efficacy of such regurgitated doses was not studied. The healthcare cannot inject the vaccine, as that would invalidate the effectiveness of the vaccine. Fourth, there may be several subtypes of rotavirus circulating in a given population. The vaccine given may not be effective against all of them, leading once again to parents’ decisions to forego vaccination. Lastly, the price is not insignificant for poor countries (a full 3 doses of Rotateq costs $8 at its cheapest, a full 2 doses of Rotatrix costs $19) (2).<br /><br /><br />There are of course, benefits of vaccinating for rotavirus using these vaccines. First, the efficacy of the two vaccines ranges from 85-98% against severe rotavirus gastroenteritis in some studies. Second, even incomplete vaccination can be protective against an infection. Third, herd immunity for older children/adults can be achieved if at least 50% of the infant population is immunized. In the case in the US, immunizing 70% of the infant population was able to largely eliminate the incidence of severe rotavirus gastroenteritis.<br /><br /><br />(1) http://www-uptodate-com.newproxy.downstate.edu/contents/rotavirus-vaccines-for-infants?source=search_result&search=rotavirus&selectedTitle=2~81<br />(2) http://www.cdc.gov/vaccines/programs/vfc/awardees/vaccine-management/price-list/<br />Mohammad Raohttps://www.blogger.com/profile/07745537034237857591noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-89639764254549914372014-07-25T13:39:42.381-04:002014-07-25T13:39:42.381-04:00Harry,
You are exactly right when you say that vac...Harry,<br />You are exactly right when you say that vaccination is the most effective way to reduce infection. In fact, since 2008, it is estimated that between 40,000-50,000 rotavirus hospitalizations of US children under 5 have been eliminated yearly. That is astounding! <br /><br />The CDC now includes the rotavirus vaccine as one of the routine vaccinations given to US infants. With that in mind, a few things should be noted about these vaccines. First, they are both live vaccines. Hence, prescribers should use caution when considering vaccination of any child with a potentially compromised immune system (ie. the rotavirus vaccines should not be administered to infants with SCID). Also, there is a slightly higher incidence of intussusception has been seen post marketing with both Rotarix and RotaTeq. Therefore, any past history of intussusception is a contraindication for these vaccines. In addition, providers should warns parents about the potential warning signs of intussusception when giving the vaccine. <br /><br />Despite these potential adverse effects though, in general, these vaccines have been a huge success story. Our current challenge is simply providing their widespread distribution, worldwide. <br />Anonymoushttps://www.blogger.com/profile/17978372461043806228noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-54536281353828410452014-07-03T16:41:56.724-04:002014-07-03T16:41:56.724-04:00Caleb's statement has some truth to it. When I...Caleb's statement has some truth to it. When I learnt about rotavirus and Oral rehydration therapy, I was under the impression that mortality from excessive diarrhea should not be a problem anymore with the therapy, which strives to provide an osmolarity isotonic to blood osmolarity but containing a high concentration of glucose. Glucose retention is very efficient in the body, and it has the added benefit of drawing hundreds of water molecules with it as it is absorbed out of the GI tract. Going back to my point, even assuming glucose is cheap and available to people in 3rd world countries, fresh water may not be easily accessible. A friend of mine who works for the peace corp in Cameroon has to walk a mile ultimately to carry back 60 lbs of water at a time for living purposes. Depending on how much support the ill child in this case has, this will determine life or death.Anonymoushttps://www.blogger.com/profile/14775669271898987660noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-607479121767144522014-06-18T13:23:07.634-04:002014-06-18T13:23:07.634-04:00Rotavirus infection transmits through the fecal-or...Rotavirus infection transmits through the fecal-oral route which causes severe diarrhea, especially in children under 5 years of age. The most effective way to reduce infection is through vaccination. According to the CDC, rotavirus vaccine is 85%-98% protective against severe rotavirus disease and 74%-87% protective against rotavirus disease of any severity in the first year after vaccination. As previously mentioned in the original article above, there are two types of vaccinations; RotaTeq and Rotarix, both administered by mouth as liquid vaccines. RotaTeq is given as a 3-dose series at ages 2 months, 4 months and 6 months, while Rotarix is given as a 2-dose at ages 2 months and 4 months. Despite using vaccination as a preventative means, we should not forget that good hygiene (such as washing hands with soap and water and boiling drinking water) is a key component to reduce the spread of the infection. Harry Persaudnoreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-65412258236445679732013-10-03T21:26:13.619-04:002013-10-03T21:26:13.619-04:00It's amazing to see how many deaths could be p...It's amazing to see how many deaths could be prevented by universal vaccination. Interventions that are related to infrastructure and sanitation would be more difficult to implement but that it not a problem with this pathogen so I think that cost and accessibility are big barriers in the reduction of rotavirus in endemic areas.Sarah Celestinhttps://www.blogger.com/profile/07678443321439290649noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-57745921881908485652013-07-17T14:32:04.298-04:002013-07-17T14:32:04.298-04:00Just for clarification, the pathogen that causes t...Just for clarification, the pathogen that causes the most cases of diarrhea is norovirus, which affects both adults and children. The introduction mentioned symbiotic virions in our gut, which I had not given much thought to before when considering our microflora (information usually focuses on the bacteria). <br /><br />Regarding rotavirus, I would guess that improving sanitation and the water supply is not sufficient to significantly reduce the morbidity and mortality of rotavirus is because of its high infectivity, much like with measles. Tamara Nowakowskihttps://www.blogger.com/profile/00270909140675173957noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-68140769469993481892013-06-21T13:20:06.647-04:002013-06-21T13:20:06.647-04:00@Cheryl makes an interesting point about potential...@Cheryl makes an interesting point about potential of waining immunity in adults after childhood vaccination. I did some research and found a CDC report (http://www.cdc.gov/vaccines/pubs/surv-manual/chpt13-rotavirus.html) that claims "no indication of waning vaccine-induced immunity has yet been observed during the rotavirus vaccine post-licensure period." This statement should be taken with a grain of salt, however, since the vaccine has only been around for ~15 years. We will not truly know the potential for waining immunity until these infants of 10 and 15 years ago come of age.Matt Boylanhttps://www.blogger.com/profile/17666172397757846346noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-78566577714564836232013-04-10T18:22:11.433-04:002013-04-10T18:22:11.433-04:00I think that Rotavirus in adults is actually more ...I think that Rotavirus in adults is actually more prevalent than stated in most text books, especially during peak months. Too much emphasis is placed on norovirus infection when an elderly patient is admitted to hospital with gastroenteritis and little thought is given to rotavirus. It can lead to weeks in hospital, AKI, aspiration pneumonia and be the source of outbreaks within hospital wards. Vaccinating children may also reduce the numbers in the community, or in turn more adults may present to hospital with rotavirus due to waining immunity.Cherylnoreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-49485041517212880932012-09-28T12:00:42.280-04:002012-09-28T12:00:42.280-04:00This entry on the rotavirus reminds me that I ofte...This entry on the rotavirus reminds me that I often take for granted the prevalence of viral inhabitants in the human body. Moreover, I was not aware that rotavirus is the most important contributor to diarrheal events in children throughout the world. I am most interested in the fact that the transmission of rotavirus is not dependent on the environmental scene. The fact that widespread implementation of the aforementioned vaccines would most likely prevent a significant number of deaths from rotavirus infection brings to mind the geopolitical setting, which must be responsible for any barrier to such implementation. I always wonder how population control plays into the evasion of such simple solutions. Anonymoushttps://www.blogger.com/profile/09270835781601639115noreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-67973062894686460502012-07-13T23:47:29.479-04:002012-07-13T23:47:29.479-04:00Waqas and Stan,
You guys make great points on the ...Waqas and Stan,<br />You guys make great points on the significance of oral rehydration therapy and the potential for OTC distribution in preventing deaths from gastrointestinal diseases. However, the places where the demand is greatest for oral rehydration therapy are also the most likely places that does not have the infrastructure there to get clean water in the first place, or to get the ingredients necessary to those areas consistently. It'd be great to see a push in that direction, but it'd still mostly be a band-aid solution. It's a little disheartening that so much of disease prevention depends on the money and stability to provide infrastructure, both of which are hard to come by.Calebnoreply@blogger.comtag:blogger.com,1999:blog-3492197469143963742.post-16157395855057299392012-06-20T15:32:45.058-04:002012-06-20T15:32:45.058-04:00This is an interesting example of the public healt...This is an interesting example of the public health benefits of two of the most important clinical interventions that medicine has devised, vaccinations and oral rehydration therapy. I found an interesting article discussing some controversy surrounding a rotavirus vaccine:<br /><br />http://articles.latimes.com/2010/mar/23/science/la-sci-vaccine23-2010mar23<br /><br />That's sort of a curiosity. Less of a curiosity, and more dangerous, is the fact that rotavirus vaccine is especially seized on in the anti-vaccination community as its inventor, Dr. Paul Offit, is held as an example of the flaws in our current system of vaccine development. This discussion provides a good example of why vaccination is so important, and why it's so important to honestly and critically analyze those in the anti-vaccination community. If sanitation and infrastructure is not adequate to control rotavirus, vaccination is made so much more important. For more information:<br /><br />http://www.npr.org/2011/01/07/132740175/paul-offit-on-the-anti-vaccine-movementAnonymoushttps://www.blogger.com/profile/05052025749936150172noreply@blogger.com